The Woods Hole Oceanographic Institution (WHOI) is seeking a Postdoctoral Investigator (PDI) to conduct research in molecular toxicology. The research will focus on the comparative biology, ligand specificity, and molecular evolution of the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that regulates the response of animals (including humans) to endogenous and exogenous chemicals.
This position is part of a project funded by the National Institute of Environmental Health Sciences (NIEHS) of the National Institutes of Health (NIH). The overall objective of the project is to elucidate the evolutionary and molecular mechanisms through which the AHR evolved as an environmental sensor recognizing diverse ligands (https://tinyurl.com/AncAHR).
This is a temporary, full-time, exempt position, and is eligible for benefits. The appointment is for 18 months with the possibility of an extension based on performance and availability of funding. The successful candidate must have a doctoral degree in an area related to the topic of the research.
WHOI has a top-rated postdoctoral program (www.whoi.edu/postdoctoral/) that supports a dynamic postdoctoral community with formal mentoring and career guidance programs. While the primary focus of the position is on research, the Postdoctoral Investigator will have the opportunity to participate in educational and outreach activities associated with the project.
WHOI has a commitment to scientific excellence and diversity, and we strongly encourage applications from candidates who will enrich and foster a culturally diverse and inclusive environment.
Essential Functions
The successful candidate will work with Drs. Mark Hahn (https://www2.whoi.edu/site/hahnlab), Sibel Karchner, and Jed Goldstone at WHOI and Dr. Joe Thornton at the University of Chicago. The PDI is expected to work well as part of a collaborative team. The research will involve 1) the use of in vitro systems (mammalian and/or yeast cell culture) to determine the ligand specificity of AHRs from a variety of animal species, and 2) reconstruction and functional analysis of ancestral AHR proteins. In addition to these laboratory-based activities, the PDI will participate in the preparation of manuscripts for submission to peer-reviewed journals and in presenting research results at national and international scientific meetings. The successful applicant should have strong written and oral communication skills, as evidenced preferably through publications in peer-reviewed scientific literature and presentations to scientific audiences.
Education & Experience
Applicants must possess (or be close to obtaining) a recent doctoral degree in toxicology, biochemistry, molecular biology, or a related discipline that would provide a foundation for the research described above. Experience with one or more of the techniques to be used is desirable but not essential. Previous postdoctoral experience is not required. Usually, scientists with more than four years of previous postdoctoral experience are not considered for these positions.
Physical Requirements
Use of hands, basic grasping, manipulation, fine manipulation, reaching above and below shoulders, prolonged/extensive standing/walking, lifting 25 lbs. or less, carrying 10 lbs. or less, bending, depth perception, far vision, near vision, hearing, talking, travel, working around others, working with others, working alone.
Applications will be reviewed starting January 1, 2024. The position will remain open until filled, with a starting date ideally in early 2024.
